Abstract
The human microbiome plays a critical role in maintaining health and influencing disease progression. With the rapid increase in emerging infectious and non-communicable diseases in India—such as antimicrobial resistance (AMR), inflammatory bowel disorders, diabetes, cancer, and post-COVID syndromes—microbiome research has gained significant attention. The integration of health informatics into microbiome science, referred to as microbiome health informatics, provides a data-driven framework for understanding host–microbe interactions, disease biomarkers, and personalized treatment strategies. This paper discusses the role of microbiome health informatics in diagnosing, predicting, and managing emerging diseases in India, emphasizing bioinformatics tools, artificial intelligence (AI), and data integration systems that support precision medicine approaches.